丹酚酸B通过调控NF-kappa;B信号通路抗心肌细胞炎症机制初探Exploration on Salvianolic acid B Regulating NF-kappa;B Signal Path to Resist Inflammatory Mechansim of Cardiac Muscle Cells摘要：药理研究已经证明：丹参主要的心血管有效成分是水溶性酚性物质，其中丹参水溶性成分丹酚酸A、丹酚酸B（Salvianolic acid A,B;Sal A,Sal B）是丹参中最重要的有效活性部位[5]。
Sal A，Sal B对缺血性脑血管疾病防治已有大量的研究报道，并有相应的新药在临床应用[6,7]，但Sal B在心血管疾病防治方面的研究则较少见系统的研究。
本文简单介绍丹酚酸B的药理作用，拟选用LPS ATP刺激H9C2细胞造模，探讨丹酚酸B是否通过调控NF-kappa;B信号通路抑制LPS ATP联合诱导引起的心肌细胞炎症反应并对其机制进行初步探究。
Abstract: The pharmacological research has proven that effective constituent of angiocarpy in the root of red-rooted salvia includes water-soluble phenolic substance. The water-soluble components in the root of red-rooted salvia include Salvianolic acid A and B(Sal A and Sal B), which are the most important effective active sites in the root of red-rooted salvia[5]. There are lots of studies about the ischemic brain blood vessel disease prevention and curing of Sal A and Sal B and there are corresponding new drugs in clinical applications[6,7].However, there are fewer systematic studies on using Sal B in cardiovascular disease prevention. In this study, the pharmacological action of Sal B was briefly introduced. LPS ATP was planned to stipulate H9C2 cellular molding to discuss whether Sal B could regulate NF-kappa;B signal path to restrain LPS ATP co-induction and result in inflammatory response of cardiac muscle cells. Moreover, the mechanism was conducted the preliminary exploration.关键词：丹酚酸B；NF-kappa;B信号通路；心肌细胞炎症Keywords: Salvianolic B; NF-kappa;B signal path: inflammation of cardiac muscle cells 1.心肌细胞炎症1.1心肌炎心肌炎是指心肌的局限性或弥漫性的炎性病变为主要表现的疾病。
心肌炎常是全身性疾病在心肌上的炎症性表现，由于心肌病变范围大小及病变程度的不同，轻者可无临床症状，严重可致猝死，诊断及时并经适当治疗者，可完全治愈，迁延不愈者，可形成慢性心肌炎或导致心肌病。
细菌性白喉杆菌、溶血性链球菌、肺炎双球菌、伤寒杆菌等。
病毒如柯萨奇病毒，艾柯病毒、肝炎病毒、流行性出血热病毒、流感病毒、腺病毒等，其他如真菌，原虫等均可致心肌炎。
但目前以病毒性心肌炎较常见。
1.2心肌炎症研究现状病毒性心肌炎现代医学尚无特效疗法，以常规治疗为主。
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